张敏 博士 讲师
邮箱: zhangmin@shou.edu.cn
研究方向：功能因子的靶向递送与可控释放
个人简介：
张敏，女，中共党员，上海海洋大学生物制药专业讲师。2022年入选“博新计划”、上海市“超级博士后”项目，上海市药学会生化药物专业委员会青年委员。主持及参与中国博士后科学基金面上项目、国家自然科学基金等多项科研项目；发表学术论文20余篇；申请多项发明专利。2021年毕业于上海海洋大学，获博士学位。2021年至2023年于中国科学院上海药物研究所开展博士后研究工作。
学术兼职：上海市药学会生化药物专业委员会青年委员
教学与课程：《有机化学C》《有机化学实验B》
学术论文：
1. Pan C#, Wang Y#, ZhangM#, Zhou T, Ye L, Tang F, Liu H, Yan Y, Gan Y. Akkermansia Muciniphila-Inspired Oral siRNA Delivery by Active Matrix-Penetration and Intracellular Endoplasmic Reticulum Accumulation. Advanced materials, 2025, e15901.
2. Song MD, Liu ZJ, Fang Z, Xu JQ, Gao XR, Zhang M*, Liu KH*. Engineered B. clausii extracellular vesicle-mediated homologous recombination impairment promotes the maintenance treatment efficacy of Olaparib in non-BRCA-mutated pancreatic cancer. Chemical Engineering Journal, 2026, 531:174116.
3. Chen F, Pan YC, Fang Z, Song MD, Zhang W, Yuan H, Gao XR, Zhang M*, Liu KH*. Camel milk extracellular vesicles-mediated co-delivery of siVEGF/sorafenib enhances the anti-hepatocellular carcinoma activity by dual-effect blocking the biological effects of VEGF, Journal of controlled release, 2025;385:113980.
4. Zhang M, Liu KH. Mechanisms of lipopolysaccharide-driven progression and metastasis of colorectal cancer. International Journal of Biological Macromolecules, 2025, 329(Pt 2):147856.
5. Wei SC, Zhang HT, Fang Z, Shi JW, Li BY, Liu ZJ, Song YH, Xu JQ, Yu Q, Zhang M*, Liu KH*. Copper complexes mediate the in situ production of reactive oxygen species in the nucleus, enhancing the anti-tumor efficacy of PTX. Results in Engineering, 2026, 29:109429.
6. Liu ZJ, Wei SC, Peng MY, Qin HQ, Wang H, Wang SQ, Wang ZY, Zhang M*, Liu KH*. Manipulating the Production and Activity of Extracellular Vesicles as Delivery Carriers through Regulation of the External Environment: A Review. Molecular pharmaceutics, 2025, 10.1021/acs.molpharmaceut.5c01054.
7. Zhang Min, Wang Yang, Gan Yong*. The potential role of Akkermansia muciniphila in liver health. Future microbiology, 2024, 19(12), 1081–1096.
8. Mingxiao Cui, Jian Ma, Wen Si, Min Zhang*, Kehai Liu*. Structural Analysis and Immunoenhancing Activity of Polysaccharides Derived From Imperatae rhizoma. Chemistry & Biodiversity,2026, 23(2):e03698.
9. Zhang M, Fang Z, Cui MX, Liu KH*. Multifunctional metal complex-based gene delivery for tumour immune checkpoint blockade combination therapy. Journal of Drug Targeting 2022, 30: 753-766.
10. Zhang M, Fang Z, Zhang HT, Cui MX, Wang MF, Liu KH*. Reversing tumor immunosuppressive microenvironment via targeting codelivery of CpG ODNs/PD-L1 peptide antagonists to enhance the immune checkpoint blockade-based anti-tumor effect. European Journal of Pharmaceutical Sciences, 2021, 168, 106044.
11. Zhang M, Guo XL, Wang MF, Liu KH*. Tumor microenvironment-induced structure changing drug/gene delivery system for overcoming delivery -associated challenges. Journal of Controlled Release, 2020, 323: 203-224.
12. Zhang M, Elango J, Guo XL, Fan H, Cui MX, Wang MF, Liu KH*. Fe3+-coordinated multifunctional elastic nanoplatform for effective in vivo gene transfection. ACS Applied Materials & Interfaces, 2020, 12: 3453-3464.
13. Zhang M, Liu KH*, Wang MF. Development of cancer immunotherapy based on PD-1/PD-L1 pathway blockade. RSC Advances, 2019, 9: 33903-33911.
14. Zhang M, Zhang TR, Zou Y, Han P, Liu KH*. Self-microemulsifying oral fast dissolving films of vitamin D3 for infants: Preparation and characterization. Food Science & Nutrition, 2019, 7: 2577-2583.
15. Zhang M, Hu J, Zou Y, Wu J, Fan H, Liu KH*, Wang J, Gao S. Modification of degradable nonviral delivery vehicle with a novel bifunctional peptide to enhance transfection in vivo. Nanomedicine, 2018, 13: 9-24.
16. Zhang M, Wu JW, Han JJ, Shu HM, Liu KH*. Isolation of polysaccharides from Dendrobium officinale leaves and anti-inflammatory activity in LPS-stimulated THP-1 cells. Chemistry Central Journal, 2018, 12, 109.
研究项目：
1. 海洋生物医药临港科创平台项目，2024.01-2025.12，主持；
2. 中国博士后科学基金会，博士后创新人才支持计划，BX20220322，2021.07-2023.07，主持；
3. 上海市人力资源和社会保障局，上海市“超级博士后”激励计划，2021430，2021.07-2023.07，主持；
4. 中国博士后科学基金会，中国博士后科学基金面上项目，2021M703354，2021.07-2023.07，主持；
5. 国家自然科学基金委，国家自然科学基金项目，81572989，2016.01-2019.12，参与;
6. 上海市科委，“科技创新行动计划”国际学术合作交流项目，18430721100，2018.10-2021.09，参与。
奖励荣誉：
1. 2018年上海海洋大学科学技术奖
2. 上海海洋大学2025年青年教师教学竞赛二等奖
课题组成员介绍：本人属于刘克海教授团队。