安海明 博士 教授 博士生导师
邮箱：andrew@shou.edu.cn
研究方向:
1. Development of novel food enzymes
Enzymes will continue to play an essential role in transforming the foods of the future. We are engineering novel enzymes using both directed evolution and machine learning methods to enhance their physicochemical properties for applications in the production of future foods with enhanced quality, nutrition, and sustainability.
2. Enhancing the nutritional value and safety of plants and seafood
Legumes and cereals contain high amounts of nutrients but also antinutritional factors. Additionally, exposure to toxic metals and metalloids via diet is a growing global public health concern. We are investigating the structure-function mechanisms of transporters of antinutritional factors and metals in major food plants and seafood. Our goal is to utilize this information to help generate future foods with enhanced nutritional value and reduced toxicity better suited for human and animal plant-rich diets.
3. Microbial biofilms: biosynthesis and control
The biofilms of food pathogenic microorganisms form an extracellular matrix which is responsible for their resistance to treatment and constitute a major problem for the food industry. We investigate the structural basis of exopolysaccharide regulation, biosynthesis and transport in major food pathogens. Structural information is used to leverage the discovery of specific inhibitors of protein-protein interactions to disrupt biofilm formation. This work is carried out in collaboration with international partners.
个人简介：
2022- Professor, College of Food Science & Technology, Shanghai Ocean University, China.
2019-2022 Professor of Structural Biology, Schools of Biological Sciences & Chemistry, UEA, UK.
2002-2019 Professor of Chemistry, Schools of Biological Sciences & Chemistry, UEA，UK.
2000-2002 Senior Lecturer, Schools of Biological Sciences & Chemistry, UEA, UK.
1994-2000 Lecturer, Schools of Biological & Chemical Sciences, UEA, UK.
1993-1994 Research Fellow, NIAS, Tsukuba, Japan.
1990-1993 Lecturer, Dept. of Crystallography, Birkbeck College, Univ. of London, UK.
1989-1990 Cray Research Fellow, Dept. of Crystallography, Birkbeck College, Univ. of London, UK.
1988-1989 Royal Society Research Fellow, 中科院Institute of Biophysics, Beijing, China.
1987-1988 Senior Research Associate, Dept. of Crystallography, Birkbeck College, Univ. of London, UK.
学术兼职：Honorary Professor, University of East Anglia, UK.
教学与课程：No formal duties
学术论文：
PUBLICATION STATISTICS
h-index 42
i10-index 84
RECENT PUBLICATIONS
1. Whitfield HL, Gilmartin M, Riley AM, Shipton ML, Potter BVL, Hemmings AM and Brearley CA.The intracellular inositol (pyro)phosphate receptor AtSPX1 reciprocally binds to P1BS DNA. Nature Commun.Accepted for publication 10th Feb 2026.
2. Griffiths R, Pfalzgraf H, Latousakis D, Ashworth G, Dong C, *Hemmings AM, Juge N. A structural basis for the strain-dependent UDP-sugar specificity of glycosyltransferase C from the Limosilactobacillus reuteri accessory secretion system. Acta Crystallogr D Struct Biol. 2025 Dec 1;81: 708-717. doi: 10.1107/S2059798325008782.
3. Sun L, Gao RJ, Shi CJ, Hemmings AM, Qian YF. Impact of collagen degradation on the textural quality of salmon (Salmo salar): A preliminary study from the perspective of endogenous collagenase and bacteria. Food Bioscience. 2025 July 2025; 69: 107003. DOI: 10.1016/j.fbio.2025.107003.
4. Bradley J, Bugg Z, Moore GR, *Hemmings AM, Le Brun NL. Observation of the assembly of the nascent mineral core at the nucleation site of human mitochondrial ferritin. J. Amer. Chem. Soc. 2025 Mar; 147: 13699–13710.DOI: 10.1021/jacs.5c01337.
5. Dudey AP, Hughes GR, Rigby JM, Monaco S, Stephenson GR, Storr TE, Angulo J, Chantry A, *Hemmings AM. 3,3′-diindolylmethane (DIM): A Molecular Scaffold for Inhibition of WWP1 and WWP2, Members of the NEDD4 Family HECT E3 Ligases. ACS Omega. 2025 Feb 9;10(6):5963-5972. DOI: 10.1021/acsomega.4c09944.
6. Zhou R, Liu Z, Wu T, Pan X, Li T, Miao K, Li Y, Hu X, Wu H, Hemmings AM, Jiang B, Zhang Z, Liu N. Machine learning-aided discovery of T790M-mutant EGFR inhibitor CDDO-Me effectively suppresses non-small cell lung cancer growth. Cell Commun Signal. 2024 Dec 5;22(1):585. DOI: 10.1186/s12964-024-01954-7.
7. Rigby JM, Chantry A, Hemmings AM, Richards CJ, Stephenson GR, Storr TE. An Improved Synthesis of 2,3-Diamino-5,6-dichloropyrazine: A Useful Heterocyclic Scaffold. Synthesis-Stuttgart. Oct 2024. DOI: 10.1055/s-0043-1775410.
8. Dudey AP, Rigby JM, Hughes GR, Stephenson GR, Storr TE, Chantry A, *Hemmings AM. Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2394895. DOI: 10.1080/14756366.2024.2394895.
9. Sharma Y, Hemmings AM, Deshmukh R, Pareek A. Metalloid transporters in plants: bridging the gap in molecular structure and physiological exaptation. J Exp Bot. 2024 Jun 7:erae261. doi: 10.1093/jxb/erae261.
10Whitfield HL, Faba-Rodriguez R, Shipton ML, Li AWH, Riley AM, Potter BVL, *Hemmings AM, Brearley CA. Crystal structure and enzymology of Solanum tuberosum inositol tris/tetrakisphosphate kinase 1 StITPK1.Biochemistry. 2023; 63(1): 42–52. DOI: 10.1021/acs.biochem.3c00404.
11 Whitfield HL, He SN, Gu YH, Sprigg C, Kuo HF, Chiou TJ, Riley AM, Potter BVL, *Hemmings AM, Brearley CA. Diversification in the inositol 1 tris/tetrakisphosphate kinase family: crystal structure and enzymology of the outlier Arabidopsis inositol tris/tetrakisphosphate kinase 4. Biochem J. 2023; 480:433-453. DOI:https://doi.org/10.1042/BCJ20220579.
12Rix GD, Sprigg C, Hemmings AM, Todd JD, Brearley CA. Characterisation of a Soil MINPP Phytase with Remarkable Long-Term Stability and Activity from Acinetobacter sp. PLOS One. 2022; 17(8): e0272015. DOI: 10.1371/journal.pone.0272015.
13Acquistapace IM, Thompson EJ, Kühn I, Bedford MR, Brearley CA, *Hemmings AM. Insights to the Structural Basis for the Stereospecificity of the Escherichia coli Phytase, AppA. Int. J. Mol. Sci. 2022; 23 (11): 6346. DOI: 10.3390/ijms23116346.
14Faba-Rodriguez R, Gu YH, Salmon M, Dionisio G, Brinch-Pedersen HA, Brearley CA, *Hemmings AM. Structure of a cereal purple acid phytase provides new insights to phytate degradation in plants. Plant Commun. 2022; 3(2):100305. DOI: 10.1016/j.xplc.2022.100305.
15Bradley JM, Fair J, Hemmings AM, LeBrun NL. Key carboxylate residues for iron transit through the prokaryotic ferritin SynFtn. Microbiology. 2021; 167(11). DOI: 10.1099/mic.0.001105
16Hughes G, Dudey A, Hemmings AM and Chantry A. Frontiers in PROTACs. Drug Discov. Today. 2021; 26(10): 2377-2383. DOI: 10.1016/j.drudis.2021.04.010.
17 Whitfield H, Hemmings AM, Mills SJ, Baker K, White G, Rushworth S, Riley AM, Potter BVL, Brearley C. Allosteric site on SHIP2 identified through fluorescent ligand screening and crystallography: a potential new target for intervention. J Med Chem .2021 Apr 8;64(7):3813-3826. DOI: 10.1021/acs.jmedchem.0c01944.
18Acquistapace IM, Ziętek MA, Li AWH, Salmon M, Kühn I, Bedford MR, Brearley CA, Hemmings AM. Snapshots during the catalytic cycle of a histidine acid phytase reveal an induced fit structural mechanism. J Biol Chem. 2020 Dec 18;295(51):17724-17737. DOI: 10.1074/jbc.RA120.015925.
19Bradley JM, Svistunenko DA, Wilson MT, Hemmings AM, Moore GR, Le Brun NE. Bacterial iron detoxification at the molecular level. J Biol Chem. 2020 Oct 12:jbc.REV120.007746. DOI: 10.1074/jbc.REV120.007746.
20Whitfield H, White G, Sprigg C, Riley AM, Potter BVL, Hemmings AM, Brearley CA. An ATP-responsive metabolic cassette comprised of inositol tris/tetrakisphosphate kinase 1 (ITPK1), inositol pentakisphosphate 2-kinase (IPK1) buffers diphosphosphoinositol phosphate levels. Biochem J. 2020 Jul 31;477(14):2621-2638. DOI: 10.1042/BCJ20200423.
21 Bradley J, Pullin J, Moore G, Svistunenko DA, Hemmings AM, Le Brun N. Routes of iron entry into,, exit from, the catalytic ferroxidase sites of the prokaryotic ferritin SynFtn. Dalton Trans. 2020, 49(5):1545-1554. DOI: 10.1039/c9dt03570b.
研究项目：
1. China Ministry of Education. Changjiang Scholar. RMB 3,000,000. 2024-2026
2. BigC Appeal. Synthesis and evaluation of X-ray structure inspired ubiquitin ligase inhibitors as anticancer lead compounds. £89k. 2020-2025. Principal Investigator.
3. Royal Society. International Exchange Award. Thermophilic Xylanases for the Sustainable Production of Nutraceuticals from Fruit Waste. Hemmings, A. £6k. 2022-2024. Principal Investigator.
4. Wellcome Trust. 106121/Z/14/Z. From structural, functional studies of essential, novel lipopolysaccharide transport, assembly membrane proteins to novel drug discoveries combating emerging multidrug-resistant pathogenic bacteria. £111k. 2020-2021. Principal Investigator.
5. BBSRC/AB Vista Feed Ingredients Ltd. DTP CASE PhD Studentship. Complete Dephosphorylation of Phytic Acid: Identification of Histidine Acid Phosphatases with Novel Phytase Activity for Use in Animal Feeds. £92k. 2019-2023. Principal Investigator.
6. BBSRC BB/R002363/1. Mechanistic studies of mitochondrial ferritin, a key player in iron mediated oxidative stress response, cellular iron metabolism. £386k. 2017-2021. Co-investigator.
7. NERC/AB Vista Feed Ingredients Ltd. DTP CASE PhD Studentship. The biodiversity of organic phosphate (phytate) cycling in soils. £90k. 2017-2021. Principal Investigator.
8. James Tudor Foundation. Further development and refinement of ubiquitin ligase inhibitors as novel cancer therapeutics. £20k 2018-2020. JointPrincipal Investigator.
9. BBSRC BB/M022978/1. Mapping the Catalytic Landscape of a Novel Phytase. £547k. 2015-2020. Principal Investigator.
10. AB Vista Feed Ingredients Ltd. BB/M022978/1. Mapping the Catalytic Landscape of a Novel Phytase. £96k. 2015-2020. Principal Investigator.
11. BBSRC BB/R013578/1. A high sensitivity elemental mass spectrometry facility to support metallobiology research on the Norwich Research Park.£349k. 2018-2019. Co-investigator.
奖励荣誉：
Fellow of the Royal Society of Chemistry (FRSC)
Fellow of the UK Higher Education Academy (FHEA)
课题组成员介绍：
See under heading ‘Team Members’ at https://andrewircfhlab.com/andrews-lab/#top