郭锐华 博士 副教授 硕士生导师
邮箱：rhguo@shou.edu.cn
研究方向:
1. 药食同源植物与海洋微生物源活性分子的发现、结构修饰及成药性评价： 以药食同源植物和海洋微生物为资源宝库，运用现代分离分析技术发现新型活性分子；通过结构修饰优化其药理活性与类药性；并结合分子、细胞及动物模型，系统评价其成药性与作用机制。
2. 食品风味品质的基础研究与标准体系构建： 聚焦食品，解析其特征风味物质的形成与变化规律，开展风味品质的基础理论研究。在此基础上，探索建立科学、客观的品质评价方法，并参与构建和完善相关的标准体系。
个人简介：
2011年于中国科学院昆明植物研究所获得博士学位，随后在中国人民解放军第二军医大学药学院从事博士后研究工作，2014年加入Kaiyun官方网站登录入口。主持科研和教改项目10余项，其中包括国家自然科学基金项目1项。在Bioorganic Chemistry和European Journal of Medicinal Chemistry等国际知名学术期刊上发表论文40余篇，授权专利6项，指导学生获得全国大学生生命科学竞赛（2021年，创新创业类）二等奖1项。
学术兼职：担任上海海洋药物专业委员会委员，。
教学与课程：
本科生课程：《药物化学》48学时、《药物合成反应》48学时、《药物化学实验》32学时；研究生课程：《高等药物化学》16学时。
学术论文：
1. Zihao Wang, Yuting Liu, Jiwen Huang, Ruihua Guo*, Min Yang*, Chaoyan Zhang*. Hydrothermal synthesis, stability, antioxidant activity and effect of carbon dots from Bletilla Striata on the growth of mung bean sprouts. ACS Applied Bio Materials,2025, 8, 10669-10681.
2. Enxiao Wang#, Lin Xing#, Lulu Li, Meidi Deng, Yuxin Ding, Chaoyan Zhang, Wenhui Wu, Ruilong Sheng, Long Huang*, Yong Shen*, Ruihua Guo*. Novel yunaconitine derivatives as protein tyrosine phosphatase 1B inhibitors and radical scavenger: Design, synthesis, in vitro cellular evaluation, and molecular docking study. Chemistry & Biodiversity, 2025, 23, e00832.
3. Lin Xing, Chi Zhang, Jieying Yuan, Kai Zhu, Helena Tomás, Ruilong Sheng, Xiuwei H. Yang, Qidong Tu*, Ruihua Guo*. Progress of ERK pathway-modulated natural products for anti-non-small-cell lung cancer activity. Pharmaceuticals, 2025, 18, 1371.
4. Rongbo Han, Junfeng Shi, Kai Cheng*, Zian Wang, Yecang Chen, Orion Spellecy, Abu Saleh Mosa Faisal, Isha Aryal, Jinfei Chen, Rolf Craven, Olivier Thibault, Lauren Baldwin, Lawrence D. Brewer, Sonia Erfani, Chi Wang, Zhenheng Guo, Eric Chen, Burton Yang, Frederick Ueland, Ruihua Guo, Xiuwei Yang*. Focal adhesion kinase intersects with the BRD4-MYC axis and YAP1 to drive tumor cell growth, phenotypic plasticity, stemness, and metastatic potential in colorectal cancer. Cancer Medicine, 2025, 14, e71227.
5. Chunhuan Bi, Xiaohui Li, Qi Xin, Wei Han, Cuiping Shi, Ruihua Guo,Wenzheng Shi,Ruirui Qiao,Xichang Wang,Jian Zhong*. Corrigendum to “Effect of extraction methods on the preparation of electrospun/electrosprayed microstructures of tilapia skin collagen” [J. Biosci. Bioeng. 128 (2) (2019) 234–240]. Journal of Bioscience and Bioengineering, 2025, 140, 269.
6. Yuxin Ding, Enxiao Wang, Lin Xing, Chaoyan Zhang, Ruilong Sheng, Wenhui Wu, Ruihua Guo*. Synthesis of isosteviol derivatives as potential anticancer agents, especially for ovarian cancer: In vitro cytotoxicity, cell cycle arrest, network pharmacology and molecular docking study. Bioorganic & Medicinal Chemistry Letters, 2025, 124, 130261.
7. Yecang Chen, Feifei Zhu, Yuxin Ding, Lin Xing, Enxiao Wang, Yixiang Fang, Ruilong Sheng, Qidong Tu*, Ruihua Guo*. Synthesis and evaluation of isosteviol derivatives: Promising anticancer therapies for colon cancer. Biomedicines, 2025, 13, 793.
8. Lin Xing, Jieying Yuan, Yuxin Ding, Enxiao Wang, Ruilong Sheng, Junting Fan*, Xiuwei H. Yang*, Ruihua Guo*. Synthesis and evaluation of demethylzeylasteral derivatives as potential anticancer therapies for colon cancer: In vitro antiproliferation, cell cycle arrest analyses, network pharmacology investigations, and molecular docking studies. Fitoterapia, 2025, 184, 106481.
9. Jianjun Zhao#, Kai Zhu#, Na Li, Lin Xing, Ruilong Sheng, Yong Shen*, Ruihua Guo*. Synthetic and pharmacological activities of alantolactone and its derivatives. Chemistry & Biodiversity, 2024, 22, e202401798.
10. Yuhang Qian, Xinye Liu, Xiangjun Zheng*, Zilong Yang, Yanjie Yu, Fei Gao, Xingmei Guo, Yuanjun Liu, Xuecheng Cao, Ruihua Guo*, Junhao Zhang*. N/S-Doped hierarchical porous bamboo carbon fibers with ultra-large surface area and highly exposed active sites for flexible zinc-air battery. Chinese Journal of Chemistry, 2024, 42, 2647-2655.
11. Sijin Hang, Wenhui Wu, Yinan Wang, Ruilong Sheng, Yiwen Fang, Ruihua Guo*. Daphnetin, a coumarin in genus stellera chamaejasme linn: Chemistry, bioactivity and therapeutic potential. Chemistry Biodiversity, 2022, 19, e202200261.
12. Sijin Hang, Hui Chen, Wenhui Wu, Shiyi Wang, Yiwen Fang, Ruilong Sheng, Qidong Tu*, Ruihua Guo*. Progress in isoindolone alkaloid derivatives from marine microorganism: Pharmacology, preparation, and mechanism. Marine Drugs, 2022, 20, 405.
13. Zhe Fu, Linjie Zhang, Sijin Hang, Shiyi Wang, Na Li, Xiaojing Sun, Zian Wang, Ruilong Sheng, Fang Wang, Wenhui Wu, Ruihua Guo*. Synthesis of coumarin derivatives: A new class of coumarin-based G protein-coupled receptor activators and inhibitors. Polymers, 2022, 14, 2021.
14. Yuebin Liu, Ruilong Sheng, Junting Fan, Ruihua Guo*. A review on structure-activity relationships of glycyrrhetinic acid derivatives with diverse bioactivities. Mini-Reviews in Medicinal Chemistry, 2022, 22, 2024-2066.
15. Xiaojing Sun, Binyu Shen, Hui Yu, Wenhui Wu, Ruilong Sheng, Yiwen Fang, Ruihua Guo*. Therapeutic potential of demethylzeylasteral, a triterpenoid of the genus Tripterygium wilfordii. Fitoterapia, 2022, 163, 05333.
16. Yinan Wang, Hui Chen, Ruilong Sheng, Zhe Fu, Junting Fan, Wenhui Wu, Qidong Tu*, Ruihua Guo*. Synthesis and bioactivities of marine pyran-isoindolone derivatives as potential antithrombotic agents. Marine Drugs, 2021, 19, 218.
17. Yinan Wang, Jiangming Wang, Zhe Fu, Ruilong Sheng, Wenhui Wu, Junting Fan, Ruihua Guo*. Syntheses and evaluation of daphnetin derivatives as novel G protein-coupled receptor inhibitors and activators. Bioorganic Chemistry, 2020, 104, 104342.
18. Jiangming Wang, Silei Lu, Ruilong Sheng, Junting Fan, Wenhui Wu and Ruihua Guo*. Structure-activity relationships of natural and synthetic indole-derived scaffolds as α-glucosidase inhibitors: A mini-review. Mini-Reviews in Medicinal Chemistry, 2020, 20, 1791-1818.
19. Changhao Bian, Jiangming Wang, Xinyi Zhou, Wenhui Wu*, Ruihua Guo*. Recent advances on marine alkaloids from sponges. Chemistry & Biodiversity, 2020, 17, e2000186.
20. Silei Lu, Jiangming Wang, Ruilong Sheng, Yiwen Fang, Ruihua Guo*. Novel bioactive polyketides isolated from marine actinomycetes: An update review from 2013 to 2019. Chemistry & Biodiversity, 2020, 17, e2000562.
21. Yang Zhang, Kai Cheng, Bingwei Xu, Junfeng Shi, Jun Qiang, Shunjin Shi, Yuanqin Yi, Hongxia Li, Tengchuan Jin, Ruihua Guo, Yadi Wu, Zeyi Liu, Xiaowei Wei*, Jian-An Huang*, Xiuwei H. Yang*. Epigenetic input dictates the threshold of targeting of the integrin-dependent pathway in non-small cell lung cancer. Frontiers in Cell and Developmental Biology, 2020, 8, 652.
22. Jiangming Wang, Changhao Bian, Yinan Wang, Quan Shea, Bin Bao, Junting Fan, Aixue Zuo*, Wenhui Wu*, Ruihua Guo*. Syntheses and bioactivities of songorine derivatives as novel G proteincoupled receptor antagonists. Bioorganic & Medicinal Chemistry, 2019, 27, 1903.
23. Jiangming Wang, Siyuan Su, Shangzhe Zhang, Shiyang Zhai, Ruilong sheng, Wenhui Wu, Ruihua Guo*. Structure-activity relationship of α-santonin derivatives with diverse bioactivities: a mini-review. European Journal of Medicinal Chemistry, 2019, 175, 215.
研究项目：
1. 乳源功能性营养成分提升与标准体系构建研究，2025.12-2028.12，上海市农业科技创新项目，子课题。
2. 鸡蛋产品风味、滋味、代谢组学、蛋白组学研究及微生物监测，2025.06-2026.02，横向，主持。
3. 猪肉产品滋味、代谢组学和蛋白组学的研究，2025.06-2026.02，横向，主持。
4. 不同烹饪条件下鸡蛋产品风味、滋味、代谢、蛋白组学研究，2025.06-2026.02，横向，主持。
5. 人工智能促进生物制药科研范式改革——以抗氧化肽研究为例，2024.01-2025.12，上海市教委，主持。
6. 微生物发酵法提纯SAL-0135-0000及其类似物，2023，横向，主持。
7. ZSK植物中抗肿瘤活性成分的评价，2022.01-2025.12，横向，主持。
8. 海洋双吲哚化合物介于uPAR诱导纤溶酶原活化溶解血栓的调控机制研究，2022.01-2025.12，国家自然科学基金委员会，参与。
9. 上海深渊生物圈前沿科学研究基地，2021.10-2026.09，上海市教育委员会，参与。
10. ZSK植物中抗肿瘤活性成分的研究，2018.04-2019.12，主持。
11. 食品学院中青年人才培育项目，2018.04-2019.12，主持。
12. 海洋双吲哚纤溶化合物的结构修饰及其构效关系研究，2016.01-2018.12，国家自然科学基金青年项目，主持。
13. 基于毒理学评价的溶血栓药物先导化合物FGFC1临床前研究，2014.10-2017.09，上海市创新行动计划，参与。
14. 海洋微生物代谢产物的分离、衍生化及纤溶活性研究，2015. 01-2016. 12，上海市校青年教师培养资助计划，主持。
15. 海洋溶栓先导化合物FGFC2结构修饰与构效关系的研究，2014.09-2016.09上海海洋大学博士科研启动，主持。
10. 抗炎的倍半萜内酯IF-24的全合成及其构-效关系初探，2012. 01-2013. 12，中国博士后科学基金面上项目，主持。
出版著作：
参编高等学校“十四五”医学规划新形态教材（药学类系列 ) 《药物化学实验指导》, 高等教育出版社，2025.
参编《基因工程药物研发的原理、途径与突破/FUNDAMENTALS, APPROACHES AND BREAKTHROUGHS IN R & D GENETICALLY ENGINEERED BIOTHERAPEUTICS》（中英文双语版），北京大学医学出版社，2023.
奖励荣誉：
2023年获得上海海洋大学教学成果，一等奖
2022年爱普奖教金，一等奖
2022年上海药学科技奖，二等奖
2021年上海海洋大学教学成果奖，一等奖
2019年度海洋科学技术奖，一等奖
2019年获得上海海洋科技术奖，二等奖
2018年获得国家海洋局海洋科学技术奖，二等奖
2015年获得上海海洋大学教学成果，二等奖